Harvoni, the hepatitis C treatment that has cured millions around the world, is made of ledipasvir 90mg and sofosbuvir 400mg.
Harvoni was first introduced in clinical trials around February, 2014 and approved by US FDA soon after.
It was a huge success to treat hepatitis C genotype 1 with Harvoni. Gilead Sciences has been credited for developing ledipasvir GS-5885.
Today, there is velpatasvir sofosbuvir combination, Epclusa, which treats all 6 genotypes of hepatitis C.
Biological Role in Hepatitis C Treatment
Ledipasvir stops the viral phosophoprotein, NS5A, from assembly, replication and secretion. Sofosbuvir, stops the RNA chain from replicating with NS5B ploymerase. Both work hand in hand to stop hepatitis C virus from replicating.
Side Effects of Ledipasvir in Hep C Treatment
Most common side effects of ledipasvir and sofosbuvir combination therapy for hepatitis C genotype 1 is headache and nausea. Overall, most hepatitis C patients tolerate the treatment well and usually no other major complications.
Drug to Drug Interactions
St. John’s Wort and rifampicin can reduce the blood concentration of ledipasvir/sofosbuvir (Harvoni), thus reducing the efficacy of hepatitis C treatment.
Clinical Studies
In phase III clinical trials, in treatment naive patients and those prior non responsive genotype 1 patients, ledipasvir and sofosbuvir showed a 100% sustained virologic response (SVR) with and without ribavirin.
The SVR was a 12 week post treatment with Harvoni.
Cost of Drug
Gilead Sciences marketed the drug at a retail price of $94,000 and a discount of $49,000 to insurance companies. Copay for most hepatitis C patients was approximately $24,000. Prices and discounts vary from city to city and state to state. You can read more about Harvoni price sticker shock here.
Treatment Controversy
According to many state laws, if their constituent/patient has a life threatening illness, a treatment must be provided. Many state healthcare budgets were not ready or prepared for the pricing of Gilead Sciences hep C meds like Sovaldi, Harvoni or Epclusa.
As a result many state healthcare budgets almost bankrupted and raking in billions of dollars in profits for Gilead.
Affordable Hepatitis C Treatment Cost
Yes, the costs of Harvoni, Sovaldi and Epclusa are not affordable by any means.
If you have been denied by your insurance company or just cannot afford the $18,000 to $24,000 copay, you can pay less than $1000 and be cured.
That cure comes with a 100% money back guarantee from Sunny Pharma.
Visit the Order page and fill out the information and we will get back to you right away. You can also give us a call 24 hours a day at 858-952-1077.
We have helped 1000s of hepatitis C patients just like you.
You will be cured.