Harvoni Side Effects Long Term

Harvoni side effects long term are few if any.  Harvoni first came out in 2014 to cure hepatitis C genotypes 1, 4, 5 or 6. It has been documented that most patients experience very few side effects on Harvoni.

Side effects of Harvoni

Harvoni is made of 90mg ledipasvir and 400mg sofosbuvir.

Harvoni side effects are generally mild and a large number of patients studied in clinical trials experienced no adverse effects. Most of the side effects experienced during treatment with Harvoni do not cause patients to seek further medical attention.

Here we will list the most common, as well as the unusual effects experienced by patients using this particular DAA(direct acting antiviral).

Note: If you experience any side effects from Harvoni or any hepatitis C medications that feel overwhelming, please contact your healthcare provider immediately.

Harvoni Side Effects Long Term
Harvoni Side Effects Long Term

Most Common Harvoni Side Effects Long Term

  • Headaches
  • Nausea
  • Diarrhea
  • Fatigue
  • Coughing
  • Lack of sleep
  • Loss of strength
  • irritability

Clinical Trials

Although there are some common side effects while taking Harvoni, many of the patients in the clinical trials were taking it with Ribavirin.

  • Throughout the trials, studies show that patients taking Ribavirin are more likely to have side effects.
  • There has been thousands of Harvoni users that claimed they had few side effects if any.
  • The percentage of patients that discontinue treatment due to intensity of side effects is less than 1%.

Less Common

  1. Dizziness
  2. Mild depression
  3. Loss of appetite
  4. Trouble concentrating (Brain fog)
  5. Feeling of discouragement

Headaches & Dizziness

Headaches are the most common side effect noted by patients who take Harvoni. Up to 29% of patients have experienced headaches, but some say they are fairly mild.

Dizziness from taking the drug is not as common, only affecting around 1% to 10%.

Physical Weakness & Fatigue

These are some of the most commonly reported effects that can be experienced. Asthenia (physical weakness) is the most common of all side effects. Reportedly around 39% of patients have experienced asthenia during treatment, while only 18% had a feeling of fatigue or tiredness.

Coughing & Dyspnea

Up to 11% of patients have experienced coughing.  Dyspnea (trouble breathing) is reported in 1% to 10%.

Insomnia, Irritability & Depression

Depression is not very common, but has been reported during clinical trials. Only 1% reported having a feeling of emptiness or depression. Many patients who did experience these feelings also battled with depression in the past.

Inability to sleep (insomnia) and irritability are known to be more common, but still reported in as little as 3% to 6%.

Nausea & Diarrhea

Nausea and diarrhea are more common side effects of Harvoni, but it only affects about 3% to 7%. Rates of people who experience this tend to rise with longer treatments.

If you have any unusual side effects please contact your healthcare team right away.  You can also call us at 858-952-1077 or email us at [email protected].